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YM90K hydrochloride
CAS No. 154164-30-4
YM90K hydrochloride( 6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)- )
Catalog No. M21946 CAS No. 154164-30-4
YM90K hydrochloride is an antagonist of AMPA receptor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 178 | In Stock |
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| 5MG | 267 | In Stock |
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| 10MG | 408 | In Stock |
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| 25MG | 672 | In Stock |
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| 50MG | 945 | In Stock |
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| 100MG | 1278 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameYM90K hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionYM90K hydrochloride is an antagonist of AMPA receptor.
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DescriptionYM90K hydrochloride is an antagonist of AMPA receptor.In a global ischemia model, YM90K (15 mg/kg i.p. x 3), NBQX (30 mg/kg i.p. x 3) and CNQX (60 mg/kg i.p. x 3) significantly prevented the delayed neuronal death in the hippocampal CA1 region in Mongolian gerbils when administered 1 h after 5-min ischemia.?In addition, the therapeutic time window for the neuroprotective effect of YM90K (30 mg/kg i.p. x 3) was 6 h. In a focal ischemia model, YM90K (30 mg/kg i.v. bolus+10 mg/kg/h for 4 h) reduced the volume of ischemic damage in the cerebral cortex in F344 rats.
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In VitroYM90K co-injected with AMPA or kainate into the rat striatum protect cholinergic neurons against AMPA- or kainate-induced neurotoxicity.
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In VivoYM90K shows potent suppressive activity against audiogenic seizure in DBA/2 mice; ED50 values of YM90K against tonic seizure is 2.54 mg/kg (i.p.). The duration of the anticonvulsant effects of YM90K is 30 min.In a global ischemia model, YM90K (15 mg/kg i.p.) significantly prevents the delayed neuronal death in the hippocampal CA1 region in Mongolian gerbils when administered 1 h after 5-min ischemia. The therapeutic time window for the neuroprotective effect of YM90K (30 mg/kg i.p.) is 6 h.In a focal ischemia model, YM90K (30 mg/kg i.v. bolus+10 mg/kg/h for 4 h) reduces the volume of ischemic damage in the cerebral cortex in F344 rats.
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Synonyms6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-
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PathwayNeuroscience
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TargetGluR
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RecptorAMPA
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Research Area——
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Indication——
Chemical Information
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CAS Number154164-30-4
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Formula Weight309.66
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Molecular FormulaC11H8ClN5O4
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Purity>98% (HPLC)
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Solubility——
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SMILESCl.[O-][N+](=O)c1cc2[nH]c(=O)c(=O)[nH]c2cc1-n1ccnc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. M ShimizuSasamata, S KawasakiYatsugi, M Okada,et al. YM90K: pharmacological characterization as a selective and potent alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate/kainate receptor antagonist.[C]// International Conference on Multimedia & Ubiquitous Engineering. IEEE Computer Society, 2007.
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